Rarest Skin Conditions Requiring Specialized Treatments

The skin is one of the most exposed organs in your body. Its sheer mass and protective functions makes it a target of so many conditions. It is at the receiving end of free radical attacks, physical abuse and failed topical treatments. The worst of all is that everything that happens to the skin is so visible that it can make you uncomfortable and affect your self-image.

Dermatology specialists account that much has been said about skin conditions and how they ought to be treated. However, not many people have seen the below conditions and how ravaging they can be on your skin.

Peeling Skin Syndrome

This is a genetic condition that can develop in both newborns and adults. Victims literally peel sheet after sheet of the top layer skin without feeling pain, only itching sensations. At times your skin gets dry, sored or even blistered.

Medical experts have identified two common occurring subtypes of this problem: noninflammatory type A and inflammatory type B. In a number of patients suffering from this condition, a gene known as transglutaminase 5 (TGM5) has been found to be mutating and possibly an indicator of how deep the problem may be.

There is no known cure for this condition. However, you can use emollients to prevent skin damage and reduce skin peeling. When blisters occur, lance them with a sterile needle and apply a light dressing on the broken skin to prevent infections.


This is literally coloured sweat. Victims of this condition have too much of a pigment known as lipofuscin that makes them give out brown, blue, green, yellow or black sweat.

The coloured sweat may appear at different points on the skin surface such as on the face, underarms, or as dark circles around the nipple area. The only way to stop this condition is to shut down the sweat glands. You could do this through a topical capsaicin cream of 0.025% concentration that is applied once or twice a day onto the affected area. Alternatively, you could try some Botox injections.

Necrobiosis Lipoidica

These are spots that appear on your shin. They are red in colour and often appear raised slightly above the skin surface. The spots have a reddish border and a yellowish centre. Because the skin is thin, it is vulnerable to splitting and when this happens, slow-healing ulcers develop. Some of these ulcers end up becoming cancerous. Treatment modalities vary but most medical practitioners recommend intralesional injections to try and slow down any active lesions.

Immunomodulating drugs like tacrolimus and ciclosporin can also be used alongside specialized therapies. Treatment may be fast-tracked or delayed depending on the stage the condition is in.

Epidermolysis Ichthyosis

This skin condition may present itself in newborns. The skin looks raw, red, and blistered. In some places, the skin thickens and becomes inflamed. If you are careful enough to look into the little furrows and folds on the skin, you may see thick hard scales developing.

Normally medical practitioners recommend a genetic test before making a conclusion as to whether or not you have this condition. There are various approaches to treatment but the tricky bit is that often times when the scales are removed, the skin becomes fragile and prone to infection.

Morgellons Disease

This disease was discovered in 1674 by Sir Thomas Browne, a British physician. The strange thing about this condition is that it arouses a stinging and biting sensation on your skin. Laboratory examinations find skin lesions that are often accompanied by protruding fibres.

When it graduates, this condition may affect memory, concentration and mood. You may also get skin rashes. Most people suffering from this condition tend to believe that they are infested with bugs.

The exact cause of the problem isn’t known as yet but there are possibilities that it is linked to a mental health problem. Most doctors suggest therapy as a possible approach to treatment.

These are just some of the few conditions whose treatment approaches are still unclear to most medical professionals. There are many others out there either waiting to be discovered or already documented. This also confirms the fact that the skin is probably one of the most complex organs in your body in structure and function.